While Ipamorelin + CJC-1295 is the most common pairing, adding Sermorelin provides an additional GHRH receptor stimulation via a slightly different binding profile. This triple combination produces peak GH pulses while remaining within negative feedback constraints u2014 unlike exogenous HGH which suppresses the HPG axis entirely.
Overview
Reconstitution Table (Multiple mL BAC water u2192 Multiple)
| Compound | Dose | Draw (U-100) |
| Ipamorelin | 200u2013300 mcg | 2u20133 Units |
| CJC-1295 no DAC | 100 mcg | 1 Unit |
| Sermorelin (optional) | 100u2013200 mcg | 0.5u20131 Unit |
All three can be combined in a single syringe and administered SC 30u201360 min before sleep. Fasting 2 hours beforehand maximises GH pulse amplitude.
The triple combination is not necessary for most users u2014 Ipamorelin + CJC-1295 alone is sufficient. Sermorelin adds marginal additional amplitude. Cycle 12 weeks on / 4 weeks off. Research use only.
Potential Benefits & Side Effects
Potential Benefits
- Maximised pulsatile GH release
- Physiological axis preservation
- Body composition improvement
- Recovery and sleep enhancement
Possible Side Effects
- Water retention
- Higher cost and complexity vs dual stack
- Potential desensitisation (cycle properly)
Storage Instructions
Lyophilized Powder
- Short-term (<3 months): Refrigerate at 2u00b0Cu20138u00b0C
- Long-term: Freeze at u221220u00b0C or lower
- Protect from light and moisture
- Allow vial to reach room temperature before opening
Reconstituted Solution
- Refrigerate at 2u00b0Cu20138u00b0C u2014 do not freeze
- Use within 28 days when reconstituted with BAC water
- Always use sterile technique when drawing doses
Important Note
This protocol guide is for educational and research purposes only. It is not medical advice. Always consult a qualified healthcare professional before using any peptide compound.