Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) was developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Based on the immunomodulatory peptide tuftsin, it modulates serotonin transport, inhibits enkephalin-degrading enzymes, and increases BDNF. Its anxiolytic effect is benzodiazepine-like without GABA-A binding u2014 no sedation, tolerance, or withdrawal.
Overview
Reconstitution Table (2 mL mL BAC water u2192 5 mg)
| Route | Dose | Frequency |
| Intranasal (preferred) | 250u2013500 mcg | Twice daily |
| Subcutaneous | 250 mcg | Once or twice daily |
Reconstitute 5 mg with 2 mL BAC water u2192 2,500 mcg/mL. For intranasal: dilute to 0.15% solution in sterile saline. Administer 1u20132 drops per nostril per dose.
Selank is approved in Russia as a nootropic and anxiolytic. Not approved in most Western jurisdictions. Research use only.
Potential Benefits & Side Effects
Potential Benefits
- Anxiety reduction without sedation
- Improved focus under stress
- BDNF upregulation
- Immunomodulation (IL-6 regulation)
- No tolerance or withdrawal
Possible Side Effects
- Mild nasal irritation (intranasal)
- Fatigue at higher doses
- Vivid dreams (uncommon)
Storage Instructions
Lyophilized Powder
- Short-term (<3 months): Refrigerate at 2u00b0Cu20138u00b0C
- Long-term: Freeze at u221220u00b0C or lower
- Protect from light and moisture
- Allow vial to reach room temperature before opening
Reconstituted Solution
- Refrigerate at 2u00b0Cu20138u00b0C u2014 do not freeze
- Use within 28 days when reconstituted with BAC water
- Always use sterile technique when drawing doses
References
Important Note
This protocol guide is for educational and research purposes only. It is not medical advice. Always consult a qualified healthcare professional before using any peptide compound.