Growth hormone release is governed by GHRH (stimulatory) and somatostatin (inhibitory). Ipamorelin reduces somatostatin tone and activates the ghrelin receptor. CJC-1295 simultaneously amplifies the stimulatory GHRH signal. Combined, they produce a GH pulse 3u201310u00d7 larger than either alone, closely mimicking natural sleep-phase GH release.
Overview
Reconstitution Table (2 mL each mL BAC water u2192 2 mg + 2 mg)
| Compound | Dose | Draw (U-100) |
| Ipamorelin | 200u2013300 mcg | 2u20133 Units |
| Mod-GRF 1-29 | 100 mcg | 1 Unit |
| Combined (same syringe) | 300 + 100 mcg | 4 Units total |
Reconstitute each with 2 mL BAC water u2192 1,000 mcg/mL each. Draw Ipamorelin first, then CJC-1295 into same syringe. Administer SC 30u201360 min before sleep.
Avoid food 2 hours before and 30 min after injection. Carbohydrates and free fatty acids blunt GH pulse. Cycle: 12 weeks on, 4 weeks off. Research use only.
Potential Benefits & Side Effects
Potential Benefits
- Synergistic GH pulse (3u201310u00d7 vs monotherapy)
- Improved sleep quality
- Body composition improvement
- Physiological axis preservation
Possible Side Effects
- Water retention
- Mild headache (initial use)
- Transient flushing
Storage Instructions
Lyophilized Powder
- Short-term (<3 months): Refrigerate at 2u00b0Cu20138u00b0C
- Long-term: Freeze at u221220u00b0C or lower
- Protect from light and moisture
- Allow vial to reach room temperature before opening
Reconstituted Solution
- Refrigerate at 2u00b0Cu20138u00b0C u2014 do not freeze
- Use within 28 days when reconstituted with BAC water
- Always use sterile technique when drawing doses
References
Important Note
This protocol guide is for educational and research purposes only. It is not medical advice. Always consult a qualified healthcare professional before using any peptide compound.