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aPeptideDictionary

Longevity & Anti-Aging Stack

Published August 27, 2026 2 min read Epitalon 10mg + SS-31 500mcg + MOTS-c 5mg + NAD+ 500mg Anti-Aging Peer-Reviewed

Overview

This stack addresses the major hallmarks of aging across different cellular compartments. Epitalon targets telomere length and circadian regulation. SS-31 preserves mitochondrial cristae structure and reduces ROS. MOTS-c restores AMPK activity and insulin sensitivity in muscle. NAD+ provides substrate for SIRT1, SIRT3, and PARP enzymes central to DNA repair and metabolic regulation.

Dosing & Reconstitution Guide

Cyclical (see each protocol) u00b7 See individual protocols u00b7 Half-life: See individual protocols

Reconstitution Table (Multiple mL BAC water u2192 Multiple)

Compound Dose Schedule
Epitalon 10 mg/day 10-day cycles, twice yearly
SS-31 0.25 mg/kg/day Daily SC, 8-week cycles
MOTS-c 5 mg Three times weekly SC
NAD+ 250u2013500 mg Monthly IV infusion or weekly IM

Run Epitalon cycles in spring and autumn. SS-31 and MOTS-c run simultaneously on 8-week cycles. NAD+ IV monthly as a foundation. Adjust based on bloodwork (IGF-1, HbA1c, telomere length panels).

This is the most research-backed anti-aging peptide stack available, combining evidence from multiple independent groups. Bloodwork monitoring is strongly recommended. Research and clinical use only.

Potential Benefits & Side Effects

Potential Benefits

  • Telomere protection (Epitalon)
  • Mitochondrial efficiency (SS-31)
  • Insulin sensitivity restoration (MOTS-c)
  • DNA repair and sirtuin activation (NAD+)
  • Multi-hallmark anti-aging coverage

Possible Side Effects

  • High protocol complexity
  • IV NAD+ requires supervision
  • Significant cost for full stack
  • Limited combined human safety data

Storage Instructions

Lyophilized Powder

  • Short-term (<3 months): Refrigerate at 2u00b0Cu20138u00b0C
  • Long-term: Freeze at u221220u00b0C or lower
  • Protect from light and moisture
  • Allow vial to reach room temperature before opening

Reconstituted Solution

  • Refrigerate at 2u00b0Cu20138u00b0C u2014 do not freeze
  • Use within 28 days when reconstituted with BAC water
  • Always use sterile technique when drawing doses

References

Khavinson V et al. (2003)

Peptide regulation of aging

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Szeto HH (2014)

Cardiolipin-protective compound SS-31

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Lee C et al. (2015)

MOTS-c regulates glucose homeostasis

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Important Note

This protocol guide is for educational and research purposes only. It is not medical advice. Always consult a qualified healthcare professional before using any peptide compound.