NAD+ is a coenzyme essential to all living cells, functioning as an electron carrier in cellular respiration and as a substrate for sirtuins (longevity enzymes) and PARPs (DNA repair enzymes). NAD+ levels decline ~50% between ages 40u201360. IV administration bypasses gut absorption variability for maximum plasma delivery.
Overview
Reconstitution Table (IV bag mL BAC water u2192 500 mg)
| Route | Dose | Duration |
| IV infusion | 250u2013500 mg | 2u20134 hours |
| IM injection | 100u2013200 mg | ~30 min |
Dissolve 500 mg in 250u2013500 mL sterile normal saline for IV infusion. Administer slowly (250 mg over minimum 2 hours). Rapid infusion causes chest tightness and nausea.
IV NAD+ should be administered by a qualified practitioner. Rapid infusion produces significant discomfort. Research and clinical use only under supervision.
Potential Benefits & Side Effects
Potential Benefits
- Cellular energy restoration
- SIRT1/SIRT3 activation
- DNA repair support via PARP
- Mitochondrial biogenesis
- Cognitive clarity (reported)
Possible Side Effects
- Chest tightness with rapid infusion
- Nausea during infusion
- Flushing
- Cramping (if too fast)
Storage Instructions
Lyophilized Powder
Store lyophilised powder at room temperature, protected from light. Refrigerate if storing long-term.
Reconstituted Solution
Use reconstituted IV solution immediately. Do not store mixed IV bags.
References
Important Note
This protocol guide is for educational and research purposes only. It is not medical advice. Always consult a qualified healthcare professional before using any peptide compound.