Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is derived from ACTH(4-7). Approved in Russia for stroke, TBI, and cognitive decline since 2011. It dramatically upregulates BDNF and its receptor TrkB, as well as NGF u2014 neurotrophins essential for neuronal survival, synaptic plasticity, and long-term potentiation.
Overview
Reconstitution Table (10 mL mL BAC water u2192 30 mg)
| Phase | Daily Dose (mg) | Units (per injection) (mL) |
|---|---|---|
| Route | Dose | Frequency |
| Intranasal | 200u2013600 mcg | Once daily morning |
| SC injection | 50u2013100 mcg | Once daily |
Reconstitute 30 mg with 10 mL saline u2192 3,000 mcg/mL. For intranasal: 1 drop per nostril = ~100 mcg. Do not use within 4 hr of sleep u2014 may cause insomnia.
Semax has a long-established safety record in Russian clinical use. Intranasal is preferred route. Research use only outside Russia.
Potential Benefits & Side Effects
Potential Benefits
- BDNF and NGF upregulation
- Stroke recovery acceleration
- Improved working memory and focus
- Neuroprotection post-injury
- Attention and learning enhancement
Possible Side Effects
- Insomnia if taken too late in the day
- Anxiety at very high doses
- Mild irritability (uncommon)
Storage Instructions
Lyophilized Powder
- Short-term (<3 months): Refrigerate at 2u00b0Cu20138u00b0C
- Long-term: Freeze at u221220u00b0C or lower
- Protect from light and moisture
- Allow vial to reach room temperature before opening
Reconstituted Solution
- Refrigerate at 2u00b0Cu20138u00b0C u2014 do not freeze
- Use within 28 days when reconstituted with BAC water
- Always use sterile technique when drawing doses
References
Dolotov OV et al. (2006)
Semax, an analog of ACTH(4-7), regulates BDNF expression in the rat brain
View SourceImportant Note
This protocol guide is for educational and research purposes only. It is not medical advice. Always consult a qualified healthcare professional before using any peptide compound.