Sermorelin acetate comprises the first 29 amino acids of endogenous GHRH (1-29) u2014 the shortest fragment retaining full biological activity. It preserves hypothalamic-pituitary axis signalling unlike exogenous HGH. FDA-approved for GH deficiency in children.
Overview
Reconstitution Table (3 mL mL BAC water u2192 9 mg)
| Phase | Dose | Frequency |
| Starting | 200 mcg | Once nightly |
| Standard | 300u2013500 mcg | Once nightly |
Reconstitute 9 mg with 3 mL BAC water u2192 3,000 mcg/mL. Standard 300 mcg dose = 1 Unit on U-100. Administer SC before sleep.
Sermorelin is subject to natural negative feedback u2014 self-limiting safety profile vs exogenous HGH. Research use only in most jurisdictions.
Potential Benefits & Side Effects
Potential Benefits
- Preserves pituitary function
- Self-limiting u2014 subject to normal feedback
- Improved sleep quality
- Lean mass support
- Lower cost than HGH with comparable efficacy in deficiency
Possible Side Effects
- Mild injection-site reactions
- Headache
- Flushing
- Hyperactivity (rare)
Storage Instructions
Lyophilized Powder
- Short-term (<3 months): Refrigerate at 2u00b0Cu20138u00b0C
- Long-term: Freeze at u221220u00b0C or lower
- Protect from light and moisture
- Allow vial to reach room temperature before opening
Reconstituted Solution
- Refrigerate at 2u00b0Cu20138u00b0C u2014 do not freeze
- Use within 28 days when reconstituted with BAC water
- Always use sterile technique when drawing doses
References
Walker RF (2006)
Sermorelin: a better approach to management of adult-onset GH insufficiency
View SourceImportant Note
This protocol guide is for educational and research purposes only. It is not medical advice. Always consult a qualified healthcare professional before using any peptide compound.